The chain said it is working closely with staff at the Barnfield Drive store to 'find alternative roles' within the business.
The company added that it is doing 'everything we can' to ensure that colleagues are supported 'during this uncertain time'.
A Wickes spokesperson added: "We can confirm that our Chichester store is to close.
"With three other Wickes stores located at Bognor Regis, Havant and Littlehampton, together with our online offering, Wickes customers will continue to be well served in the local area."
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